Are harmful substances such as hexavalent chromium, formaldehyde, and azo dyes really harmful to the human body?

Hexavalent chromium remaining in leather can be absorbed through the skin and respiratory tract, causing damage to the gastrointestinal tract, liver, and kidneys, as well as eye injuries, retinal hemorrhage, optic nerve atrophy, etc.; leather, artificial leather used in shoe uppers, etc. Synthetic leathers and textiles, etc., may contain formaldehyde and azo dyes, both of which are mainly derived from auxiliaries. If the skin is exposed to formaldehyde for a long period of time, the skin may be dry, chapped, and eczema may develop. It may also lead to contact dermatitis and affect the liver function, resulting in symptoms such as loss of appetite, leading to dysplasia; azo dyes can be absorbed by the skin and spread in the body Under special conditions, it can decompose and produce 22 carcinogenic aromatic amines, causing lesions and inducing cancer.

"Benzene poisoning" is one of the occupational diseases of shoe-worn workers. The harm to the human body is particularly serious, because benzene-based adhesives are often used in shoemaking. In 1993, the International Agency for Research on Cancer (IARC) affiliated with the world’s unfamiliar organization rated benzene as “a category of human carcinogens”. Through breathing or long-term contact with the skin, benzene is absorbed by the body and DNA can be broken and displaced, leading to cell canceration and leukemia.
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